Dna Topoisomerase Protocols Dna Topology And Enzymes hardcover english - 1999
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| Publisher | Springer |
| ISBN 13 | 9780896034440 |
| Book Description | Beginning with the Escherichia coli co protein, or bacterial DNA topoisomerase I, an ever-increasing number of enzymes has been identified that catalyze changes in the linkage of DNA strands. DNA topoisomerases are ubiquitous in nature and have been shown to play critical roles in most p- cesses involving DNA, including DNA replication, transcription, and rec- bination. These enzymes further constitute the cellular targets of a number of clinically important antibacterial and anticancer agents. Thus, further studies of DNA topology and DNA topoisomerases are critical to advance our und- standing of the basic biological processes required for cell cycle progression, cell division, genomic stability, and development. In addition, these studies will continue to provide critical insights into the cytofoxic action of drugs that target DNA topoisomerases. Such mechanistic studies have already played an important role in the development and clinical application of antimicrobial and chemotherapeutic agents. The two volumes of DNA Topois |
| Language | English |
| Author | Mary.Bjornsti |
| Publication Date | 1999 |
| Number of Pages | 327 |
Dna Topoisomerase Protocols Dna Topology And Enzymes hardcover english - 1999
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