1. Sterilize, wash and pat dry the cartridges. 2. Move around the desired area for 2-4 times. Use the pointing and tapping method as much as possible during the first operation. (Gently point to the part of the face to be treated, do not try hard.) 3. Apply moisturizer or repair serum after use. (The cartridges are best for single use, do not share cartridges with others, avoid cross-infection.) 4. Experts recommend using the Derma Pen Microneedle with topical anesthetic cream and Vitamin C serum together.