The game is set in Raccoon City during a zombie apocalypse caused by an outbreak of the T-Virus that was created by pharmaceutical company Umbrella Corporation
Former Special Tactics And Rescue Service (S.T.A.R.S.) member Jill Valentine is attacked in her apartment by an Umbrella-created intelligent bioweapon known as Nemesis
After another encounter with Nemesis, she is saved by Umbrella Biohazard Countermeasure Service (U.B.C.S.) mercenary Carlos Oliveira
Carlos and his group of surviving U.B.C.S. mercenaries - Mikhail Victor, Tyrell Patrick, and Nicholai Ginovaef - have set up subway trains which they plan to use to evacuate civilians from the city
Jill manages to reactivate power to the subway, while Carlos and Tyrell remain in the city to search for Dr. Nathaniel Bard, an Umbrella scientist who might know how to make a vaccine for the T-virus and save the city