Mode of application: Gel or cream evenly applied with a thin layer to the affected skin 1 time a day before going to bed (protect the area around the eyes and lips!). The drug should be applied to clean, dry skin. The therapeutic effect develops after 4-8 weeks of therapy, persistent improvement - after 3 months from the start of therapy. Typically, therapy begins with a gel, with sensitive and dry skin, as well as in the autumn-winter season, Differin cream containing moisturizing components is shown in the skin.