Systems Biology: Constraint-Based Reconstruction and Analysis hardcover english
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| Publisher | Cambridge University Press |
| ISBN 13 | 9781107038851 |
| Book Description | Recent technological advances have enabled comprehensive determination of the molecular composition of living cells. The chemical interactions between many of these molecules are known giving rise to genomescale reconstructed biochemical reaction networks underlying cellular functions. Mathematical descriptions of the totality of these chemical interactions lead to genomescale models that allow the computation of physiological functions. Reflecting these recent developments this textbook explains how such quantitative and computable genotypephenotype relationships are built using a genomewide basis of information about the gene portfolio of a target organism. It describes how biological knowledge is assembled to reconstruct biochemical reaction networks the formulation of computational models of biological functions and how these models can be used to address key biological questions and enable predictive biology. Developed through extensive classroom use the book is designed to provide students with a solid conceptual framework and an invaluable set of modeling tools and computational approaches. |
| About the Author | Bernhard O. Palsson is the Galletti Professor of Bioengineering and Professor of Pediatrics at the University of California, San Diego. For almost 30 years, his research has focused on the development of large-scale models of biological functions and their use to solve basic and applied problems in the life sciences. He has authored three previous textbooks. |
| Language | English |
| Author | Bernhard O.Palsson |
| Edition Number | 1 |
| Number of Pages | 550 |
Systems Biology: Constraint-Based Reconstruction and Analysis hardcover english
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